Name: BRD3731
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214435721
Cas No:2056262-07-6
常用名:BRD3731
IUPAC:(4S)-3-(2,2-dimethylpropyl)-4,7,7-trimethyl-4-phenyl-2H,4H,5H,6H,7H,8H,9H-pyrazolo[3,4-b]quinolin-5-one
IUPAC:(4S)-3-(2,2-dimethylpropyl)-4,7,7-trimethyl-4-phenyl-2H,4H,5H,6H,7H,8H,9H-pyrazolo[3,4-b]quinolin-5-one
InChI key:YZRXTIGAQRIAEX-XMMPIXPASA-N

分子式:C24H31N3O
分子量:377.532
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)(C)Cc1[nH]nc2NC3=C(C(=O)CC(C)(C)C3)[C@](C)(c12)c1ccccc1
SMILES:CC(C)(C)Cc1[nH]nc2NC3=C(C(=O)CC(C)(C)C3)[C@](C)(c12)c1ccccc1

BRD3731 is a selective inhibitor of GSK3β, demonstrating an IC50 value of 15 nM for GSK3β and 215 nM for GSK3α. Due to its inhibitory properties, BRD3731 holds promise for investigating various medical conditions, including post-traumatic stress disorder (PTSD), psychiatric disorders, diabetes, and neurodegenerative disorders [1].

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