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  3. HIT214435733
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HIT214435733
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HIT214435733
  • HIT ID:HIT214435733
  • Cas No:1430095-30-9
  • 常用名:JAK3-IN-9
  • IUPAC:4-[(5-carbamoyl-4-{[(2R)-3-methylbutan-2-yl]amino}pyrimidin-2-yl)amino]phenyl methanesulfonate
    IUPAC:4-[(5-carbamoyl-4-{[(2R)-3-methylbutan-2-yl]amino}pyrimidin-2-yl)amino]phenyl methanesulfonate
  • InChI key:PPLPVIMTEDXJNJ-LLVKDONJSA-N
  • 分子式:C17H23N5O4S
  • 分子量:393.46
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC(C)[C@@H](C)Nc1nc(Nc2ccc(OS(C)(=O)=O)cc2)ncc1C(N)=O
    SMILES:CC(C)[C@@H](C)Nc1nc(Nc2ccc(OS(C)(=O)=O)cc2)ncc1C(N)=O
  • JAK3-IN-9 is a potent and orally active inhibitor of the Janus kinase 3 (JAK3) enzyme, displaying an impressive IC50 value of 1.7 nM. It exhibits high selectivity towards the JAK3 signaling pathway, making it a valuable tool for studying autoimmune diseases. Additionally, JAK3-IN-9 possesses desirable characteristics such as low toxicity and excellent oral bioavailability. It also demonstrates promising anti-arthritis activity, thus enhancing its potential as a therapeutic agent [1].
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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