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  3. HIT214435939
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HIT214435939
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HIT214435939
  • HIT ID:HIT214435939
  • Cas No:2636771-29-2
  • 常用名:PKC-IN-4
  • IUPAC:1-{1-[5-(pyridin-4-yl)-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-3-yl]piperidin-4-yl}methanamine
    IUPAC:1-{1-[5-(pyridin-4-yl)-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-3-yl]piperidin-4-yl}methanamine
  • InChI key:TXGUECVFNFKTBD-UHFFFAOYSA-N
  • 分子式:C21H25N5S
  • 分子量:379.53
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:NCC1CCN(CC1)c1nc(nc2sc3CCCCc3c12)-c1ccncc1
    SMILES:NCC1CCN(CC1)c1nc(nc2sc3CCCCc3c12)-c1ccncc1
  • PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM. In vitro studies have demonstrated that PKC-IN-4 effectively suppresses NF-κB activity induced by TNF-α. Moreover, this compound effectively impedes the permeability of the retinal vasculature, induced by both VEGF and TNFα. [1]
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 14,900.00
    1

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