Name: AChE-IN-21
Rating: 5 (10 reviews)

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HIT ID:HIT214435952
Cas No:2413656-04-7
常用名:AChE-IN-21
IUPAC:(3Z)-3-{6-[benzyl(methyl)amino]hexylidene}-5,6-dimethoxy-1,3-dihydro-2-benzofuran-1-one
IUPAC:(3Z)-3-{6-[benzyl(methyl)amino]hexylidene}-5,6-dimethoxy-1,3-dihydro-2-benzofuran-1-one
InChI key:WHYYJDIDWYSXOY-BKUYFWCQSA-N

分子式:C24H29NO4
分子量:395.499
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc2C(=O)O\C(=C/CCCCCN(C)Cc3ccccc3)c2cc1OC
SMILES:COc1cc2C(=O)O\C(=C/CCCCCN(C)Cc3ccccc3)c2cc1OC

AChE-IN-21 (Compound I-8) is a highly potent and selective orally active inhibitor of acetylcholinesterase (AChE). It exhibits an impressive inhibitory concentration (IC50) of 2.66 nM. Additionally, AChE-IN-21 demonstrates excellent in vitro blood-brain barrier (BBB) permeability [1].

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