Name: PIM1-IN-7
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214436209
Cas No:2439168-72-4
常用名:PIM1-IN-7
IUPAC:N-(2,6-dimethylphenyl)-5,7-dimethyl-2-(phenylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide
IUPAC:N-(2,6-dimethylphenyl)-5,7-dimethyl-2-(phenylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide
InChI key:BESUIJNZKPSODK-UHFFFAOYSA-N

分子式:C23H23N5O
分子量:385.471
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1cc(C)n2nc(Nc3ccccc3)c(C(=O)Nc3c(C)cccc3C)c2n1
SMILES:Cc1cc(C)n2nc(Nc3ccccc3)c(C(=O)Nc3c(C)cccc3C)c2n1

PIM1-IN-7 (compound 6c) is a powerful inhibitor of PIM-1, effectively suppressing its activity with an IC50 of 0.67 μM. This compound also exhibits significant cytotoxicity against HCT-116 and MCF-7 cells, as demonstrated by their respective IC50 values of 42.9 and 7.68 μM [1].

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