Name: IDO1/TDO-IN-3
Rating: 5 (10 reviews)

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HIT ID:HIT214436212
Cas No:2347579-03-5
常用名:IDO1/TDO-IN-3
IUPAC:1-(3-chloro-4-fluorophenyl)-6-fluoro-1H,4H,9H-naphtho[2,3-d][1,2,3]triazole-4,9-dione
IUPAC:1-(3-chloro-4-fluorophenyl)-6-fluoro-1H,4H,9H-naphtho[2,3-d][1,2,3]triazole-4,9-dione
InChI key:KGLAAILBKHAJFQ-UHFFFAOYSA-N

分子式:C16H6ClF2N3O2
分子量:345.69
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Fc1ccc2C(=O)c3c(nnn3-c3ccc(F)c(Cl)c3)C(=O)c2c1
SMILES:Fc1ccc2C(=O)c3c(nnn3-c3ccc(F)c(Cl)c3)C(=O)c2c1

IDO1/TDO-IN-3 is a powerful inhibitor targeting IDO1 and TDO enzymes. It displays noteworthy effectiveness against IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM). Additionally, IDO1/TDO-IN-3 demonstrates considerable in vivo anti-tumor properties while exhibiting no apparent toxicity [1].

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