Name: HIV-1 inhibitor-35
Rating: 5 (10 reviews)

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HIT ID:HIT214436302
Cas No:2416971-32-7
常用名:HIV-1 inhibitor-35
IUPAC:N-(5-chloro-1,3-thiazol-2-yl)-4-(5,6-dichloropyridin-3-yl)piperazine-1-carboxamide
IUPAC:N-(5-chloro-1,3-thiazol-2-yl)-4-(5,6-dichloropyridin-3-yl)piperazine-1-carboxamide
InChI key:RBHIWEJLJQXJSA-UHFFFAOYSA-N

分子式:C13H12Cl3N5OS
分子量:392.68
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Clc1cnc(NC(=O)N2CCN(CC2)c2cnc(Cl)c(Cl)c2)s1
SMILES:Clc1cnc(NC(=O)N2CCN(CC2)c2cnc(Cl)c(Cl)c2)s1

HIV-1 inhibitor-35 (compound 74) is a highly potent inhibitor of the HIV-1 virus, exhibiting EC50 values of 80 nM and 70 nM for LTR and CMV, respectively, in HEK293 cells. Additionally, HIV-1 inhibitor-35 demonstrates inhibitory activity against HepG2 liver cancer cells, with a CC50 value of 40 nM. Moreover, HIV-1 inhibitor-35 shows promise as a potential HIV-1 latency reversing agent [1].

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