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  3. HIT214437892
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HIT214437892
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HIT214437892
  • HIT ID:HIT214437892
  • Cas No:2761542-55-4
  • 常用名:AChE/BChE-IN-9
  • IUPAC:(2E)-3-(4-hydroxy-3-methoxyphenyl)-N-{[(1H-indol-5-yl)carbamoyl]methyl}prop-2-enamide
    IUPAC:(2E)-3-(4-hydroxy-3-methoxyphenyl)-N-{[(1H-indol-5-yl)carbamoyl]methyl}prop-2-enamide
  • InChI key:XVKHPTDTSZLRHX-XVNBXDOJSA-N
  • 分子式:C20H19N3O4
  • 分子量:365.389
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1cc(\C=C\C(=O)NCC(=O)Nc2ccc3[nH]ccc3c2)ccc1O
    SMILES:COc1cc(\C=C\C(=O)NCC(=O)Nc2ccc3[nH]ccc3c2)ccc1O
  • AChE/BChE-IN-9 (Compound 7a) is a potent orally active inhibitor of AChE and BChE, with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. It also demonstrates effective antioxidant activity, with an IC50 value of 57.35 μM. Additionally, AChE/BChE-IN-9 exhibits the ability to chelate iron and modulate the aggregation of amyloid β 1-42. Notably, AChE-IN-16 has the ability to cross the blood-brain barrier [1].
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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