Name: SCH-42354
Rating: 5 (10 reviews)

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HIT ID:HIT214437971
Cas No:144505-58-8
常用名:SCH-42354
IUPAC:(2S)-2-[(2S)-2-[(2-methylphenyl)methyl]-3-sulfanylpropanamido]-4-(methylsulfanyl)butanoic acid
IUPAC:(2S)-2-[(2S)-2-[(2-methylphenyl)methyl]-3-sulfanylpropanamido]-4-(methylsulfanyl)butanoic acid
InChI key:FGXXIAHRYGHABD-KGLIPLIRSA-N

分子式:C16H23NO3S2
分子量:341.48
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CSCC[C@H](NC(=O)[C@@H](CS)Cc1ccccc1C)C(O)=O
SMILES:CSCC[C@H](NC(=O)[C@@H](CS)Cc1ccccc1C)C(O)=O

SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP), serving as the active form of the prodrug SCH-42495. By inhibiting NEP hydrolysis, SCH-42354 enhances the activity of atrial natriuretic peptide (ANP) and prevents the hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. Furthermore, SCH-42354 exhibits antihypertensive activity [1] [2].

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