Name: 4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt)
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HIT ID:HIT214472305
Cas No:206443-06-3
常用名:4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt)
常用名:4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt)
IUPAC:sodium [(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]oxan-2-yl]methyl sulfate
IUPAC:sodium [(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]oxan-2-yl]methyl sulfate
InChI key:KHTOBGQRIASILC-XNSOHGFJSA-M

分子式:C16H17NaO11S
分子量:440.35
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na+].Cc1cc(=O)oc2cc(O[C@@H]3O[C@H](COS([O-])(=O)=O)[C@H](O)[C@H](O)[C@H]3O)ccc12
SMILES:[Na+].Cc1cc(=O)oc2cc(O[C@@H]3O[C@H](COS([O-])(=O)=O)[C@H](O)[C@H](O)[C@H]3O)ccc12

4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity. 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient. 4-MU-Gal-6S can be used to assess GALNS activity in a very small blood volume to determine the extent of deficiency.

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