Name: Maprotiline-d3 hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214982246
Cas No:1329496-63-0
常用名:Maprotiline-d3 hydrochloride
IUPAC:(2H3)methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9,11,13-hexaen-1-yl}propyl)amine hydrochloride
IUPAC:(2H3)methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9,11,13-hexaen-1-yl}propyl)amine hydrochloride
InChI key:NZDMFGKECODQRY-NIIDSAIPSA-N

分子式:C20H24ClN
分子量:316.89
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.[2H]C([2H])([2H])NCCCC12CCC(c3ccccc13)c1ccccc21
SMILES:Cl.[2H]C([2H])([2H])NCCCC12CCC(c3ccccc13)c1ccccc21

Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline also reduces aggressive behavior in rhesus monkeys housed in groups. Formulations containing maprotiline have been used in the treatment of depression and anxiety.

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