Name: R 59-022 hydrochloride
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214982743
Cas No:93076-98-3
常用名:R 59-022 hydrochloride
别名:DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride, DKGI-I hydrochloride, Diacylglycerol kinase inhibitor I hydrochloride
别名:DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride, DKGI-I hydrochloride, Diacylglycerol kinase inhibitor I hydrochloride
IUPAC:6-(2-{4-[(4-fluorophenyl)(phenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one hydrochloride
IUPAC:6-(2-{4-[(4-fluorophenyl)(phenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one hydrochloride
InChI key:APNKGVNEUKASGR-UHFFFAOYSA-N

分子式:C27H27ClFN3OS
分子量:496.04
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccccc1)c1ccc(F)cc1
SMILES:Cl.Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccccc1)c1ccc(F)cc1

R 59-022 hydrochloride (DKGI-I hydrochloride) 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 hydrochloride 是一种 DGK 抑制剂 (IC50:2.8 µM),可抑制 OAG 磷酸化为 OAPA。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。

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