Name: UZH1
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214982858
Cas No:2925713-02-4
常用名:UZH1
别名:UZH1
IUPAC:N-({1-[6-(benzylamino)pyrimidin-4-yl]-3-hydroxypiperidin-3-yl}methyl)-4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-hydroxybenzamide
IUPAC:N-({1-[6-(benzylamino)pyrimidin-4-yl]-3-hydroxypiperidin-3-yl}methyl)-4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-hydroxybenzamide
InChI key:PWYRDVXYAOGDNK-UHFFFAOYSA-N

分子式:C32H42N6O3
分子量:558.727
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC1(C)CCN(Cc2ccc(C(=O)NCC3(O)CCCN(C3)c3cc(NCc4ccccc4)ncn3)c(O)c2)CC1
SMILES:CC1(C)CCN(Cc2ccc(C(=O)NCC3(O)CCCN(C3)c3cc(NCc4ccccc4)ncn3)c(O)c2)CC1

UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1b (IC50=28 μM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor activity. UZH1 also can be used as a chemical probe for studying METTL3[1].

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