Name: Avatrombopag hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214983030
Cas No:570403-17-7
常用名:Avatrombopag hydrochloride
别名:YM477hydrochloride, E5501hydrochloride, AKR-501 hydrochloride
别名:YM477hydrochloride, E5501hydrochloride, AKR-501 hydrochloride
IUPAC:1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid hydrochloride
IUPAC:1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid hydrochloride
InChI key:JSHJSCRYBTVFTI-UHFFFAOYSA-N

分子式:C29H35Cl3N6O3S2
分子量:686.11
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(-c2cc(Cl)cs2)c(s1)N1CCN(CC1)C1CCCCC1
SMILES:Cl.OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(-c2cc(Cl)cs2)c(s1)N1CCN(CC1)C1CCCCC1

Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC 50 of 3.3 nM. It effectively mimics the biological activities of TPO, stimulating platelet production by activating the intracellular signaling system and facilitating the generation of platelets and megakaryocytes from hemopoietic precursor cells. Additionally, Avatrombopag hydrochloride serves as a substrate for cytochrome P450 (CYP) 2C9 and CYP3A.

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