Name: Cys-McMMAF
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214983280
Cas No:1160590-05-5
常用名:Cys-McMMAF
IUPAC:(2R)-2-amino-3-{[1-(5-{[(1S)-1-{[(1S)-1-{[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)carbamoyl}-2-methylpropyl]carbamoyl}-2-methylpropyl](methyl)carbamoyl}pentyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}propanoic acid
IUPAC:(2R)-2-amino-3-{[1-(5-{[(1S)-1-{[(1S)-1-{[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)carbamoyl}-2-methylpropyl]carbamoyl}-2-methylpropyl](methyl)carbamoyl}pentyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}propanoic acid
InChI key:BXTJCSYMGFJEID-XMTADJHZSA-N

分子式:C52H83N7O13S
分子量:1046.33
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]1(CCCN1C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)CC(SC[C@H](N)C(O)=O)C1=O)C(C)C)[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
SMILES:[H][C@]1(CCCN1C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)CC(SC[C@H](N)C(O)=O)C1=O)C(C)C)[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O

Cys-McMMAF 是 AlMcMMAF 释放的有效载荷，AlMcMMAF 是一种抗 5T4 的人源化 A1 抗体，通过马来酰咪唑丙基连接物偶联到微管破坏 MMAF 。Cys-McMMAF 对两种肿瘤小鼠模型(H1975 和 MDA-MB-361-DYT2 模型) 均有抑癌效果。

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