Roridin E | CAS 16891-85-3 | AnyMole

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HIT217565527

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HIT217565527

HIT ID:HIT217565527
Cas No:16891-85-3
常用名:Roridin E
IUPAC:(12'E,18'E,20'E)-17'-(1-hydroxyethyl)-5',13',25'-trimethyl-2',10',16',23'-tetraoxaspiro[oxirane-2,26'-tetracyclo[22.2.1.0^{3,8}.0^{8,25}]heptacosane]-4',12',18',20'-tetraene-11',22'-dione
IUPAC:(12'E,18'E,20'E)-17'-(1-hydroxyethyl)-5',13',25'-trimethyl-2',10',16',23'-tetraoxaspiro[oxirane-2,26'-tetracyclo[22.2.1.0^{3,8}.0^{8,25}]heptacosane]-4',12',18',20'-tetraene-11',22'-dione
InChI key:KEEQQEKLEZRLDS-UZFWBDJGSA-N

分子式:C29H38O8
分子量:514.615
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(O)C1OCC\C(C)=C\C(=O)OCC23CCC(C)=CC2OC2CC(OC(=O)\C=C\C=C\1)C3(C)C21CO1
SMILES:CC(O)C1OCC\C(C)=C\C(=O)OCC23CCC(C)=CC2OC2CC(OC(=O)\C=C\C=C\1)C3(C)C21CO1

Roridin E inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 μM, respectively) and induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM). It also inhibits proliferation in a panel of additional cancer cell lines (IC50s = <0.01 μM).

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TargetMolSC
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35日内发货
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¥ 3,780.00
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