Name: MC-GGFG-AM-(10NH2-11F-Camptothecin)
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT217583462
Cas No:2873460-71-8
常用名:MC-GGFG-AM-(10NH2-11F-Camptothecin)
常用名:MC-GGFG-AM-(10NH2-11F-Camptothecin)
IUPAC:6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-{[({[(1S)-1-[({[(19R)-19-ethyl-6-fluoro-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]carbamoyl}methyl)carbamoyl]-2-phenylethyl]carbamoyl}methyl)carbamoyl]methyl}hexanamide
IUPAC:6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-{[({[(1S)-1-[({[(19R)-19-ethyl-6-fluoro-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]carbamoyl}methyl)carbamoyl]-2-phenylethyl]carbamoyl}methyl)carbamoyl]methyl}hexanamide
InChI key:GLUCBNJSQUGNCA-OXCVABKISA-N

分子式:C45H45FN8O11
分子量:892.898
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC[C@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(NC(=O)CNC(=O)[C@H](Cc5ccccc5)NC(=O)CNC(=O)CNC(=O)CCCCCN5C(=O)C=CC5=O)cc4cc3Cn1c2=O
SMILES:CC[C@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(NC(=O)CNC(=O)[C@H](Cc5ccccc5)NC(=O)CNC(=O)CNC(=O)CCCCCN5C(=O)C=CC5=O)cc4cc3Cn1c2=O

MC-GGFG-AM-(10NH2-11F-Camptothecin) 是一种ADC，其通过pH敏感的可水解连接物与Trop-2针对性抗体sacituzumab偶联，展现出针对癌症的活性，适用于癌症研究领域。

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