Name: MC-VC-PABC-C6-alpha-Amanitin
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT217583463
Cas No:2922514-69-8
常用名:MC-VC-PABC-C6-alpha-Amanitin
IUPAC:{4-[(2R)-5-(carbamoylamino)-2-[(2R)-2-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido]-3-methylbutanamido]pentanamido]phenyl}methyl N-(6-{[(1R,4S,8R,10S,13S,16S,34S)-34-[(2S)-butan-2-yl]-4-(carbamoylmethyl)-13-[(2R,3R)-3,4-dihydroxybutan-2-yl]-8-hydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27lambda4-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0^{6,10}.0^{18,26}.0^{19,24}]nonatriaconta-18(26),19,21,23-tetraen-22-yl]oxy}hexyl)carbamate
IUPAC:{4-[(2R)-5-(carbamoylamino)-2-[(2R)-2-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido]-3-methylbutanamido]pentanamido]phenyl}methyl N-(6-{[(1R,4S,8R,10S,13S,16S,34S)-34-[(2S)-butan-2-yl]-4-(carbamoylmethyl)-13-[(2R,3R)-3,4-dihydroxybutan-2-yl]-8-hydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27lambda4-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0^{6,10}.0^{18,26}.0^{19,24}]nonatriaconta-18(26),19,21,23-tetraen-22-yl]oxy}hexyl)carbamate
InChI key:DSGDZYMYBLNPSD-YEZOBKOJSA-N

分子式:C74H105N17O22S
分子量:1616.81
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12C[C@@H](O)CN1C(=O)[C@H](CC(N)=O)NC(=O)[C@]1([H])CS(=O)c3[nH]c4cc(OCCCCCCNC(=O)OCc5ccc(NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](NC(=O)CCCCCN6C(=O)C=CC6=O)C(C)C)cc5)ccc4c3C[C@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@@H](C)[C@@H](O)CO)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)N1
SMILES:[H][C@@]12C[C@@H](O)CN1C(=O)[C@H](CC(N)=O)NC(=O)[C@]1([H])CS(=O)c3[nH]c4cc(OCCCCCCNC(=O)OCc5ccc(NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](NC(=O)CCCCCN6C(=O)C=CC6=O)C(C)C)cc5)ccc4c3C[C@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@@H](C)[C@@H](O)CO)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)N1

MC-VC-PABC-C6-alpha-Amanitin是一款针对HER2受体的ADC，包含致癌毒素alpha-Amanitin及单克隆抗体MC-VC-PABC-C6。alpha-Amanitin主要抑制RNA聚合酶IIα。该化合物专一性地靶向HER2阳性肿瘤细胞，主要应用于乳腺癌与胃癌的研究领域。

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~