Name: MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT217583464
Cas No:2873460-72-9
常用名:MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)
常用名:MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)
IUPAC:6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-{[({[(1S)-1-[({[(19R)-19-ethyl-6-fluoro-19-hydroxy-10-(hydroxymethyl)-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]carbamoyl}methyl)carbamoyl]-2-phenylethyl]carbamoyl}methyl)carbamoyl]methyl}hexanamide
IUPAC:6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-{[({[(1S)-1-[({[(19R)-19-ethyl-6-fluoro-19-hydroxy-10-(hydroxymethyl)-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]carbamoyl}methyl)carbamoyl]-2-phenylethyl]carbamoyl}methyl)carbamoyl]methyl}hexanamide
InChI key:IQSVCRAHKRDQOX-HCPWKLSCSA-N

分子式:C46H47FN8O12
分子量:922.924
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC[C@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(NC(=O)CNC(=O)[C@H](Cc5ccccc5)NC(=O)CNC(=O)CNC(=O)CCCCCN5C(=O)C=CC5=O)cc4c(CO)c3Cn1c2=O
SMILES:CC[C@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(NC(=O)CNC(=O)[C@H](Cc5ccccc5)NC(=O)CNC(=O)CNC(=O)CCCCCN5C(=O)C=CC5=O)cc4c(CO)c3Cn1c2=O

MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) (compound 141) 为ADC用途的drug-linker conjugate，其结构包括7ethanol-10NH2-11F-Camptothecin 与蛋白酶可降解(cleavable)的MC-GGFG通过化学键连接形成。

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