Name: Uroguanylin-15 (Rat)
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT217584568
Cas No:
常用名:Uroguanylin-15 (Rat)
IUPAC:(1R,4S,10S,13S,16R,19S,22S,25R,32S,38R)-25-[(2S)-2-[(2S)-2-[(2S,3R)-2-amino-3-hydroxybutanamido]-3-carboxypropanamido]-4-carboxybutanamido]-13-[(2S)-butan-2-yl]-10-(carbamoylmethyl)-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7-(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracontane-38-carboxylic acid
IUPAC:(1R,4S,10S,13S,16R,19S,22S,25R,32S,38R)-25-[(2S)-2-[(2S)-2-[(2S,3R)-2-amino-3-hydroxybutanamido]-3-carboxypropanamido]-4-carboxybutanamido]-13-[(2S)-butan-2-yl]-10-(carbamoylmethyl)-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7-(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracontane-38-carboxylic acid
InChI key:MTYHWKJCMMEKJX-DMHVAJGLSA-N

分子式:C60H96N16O25S4
分子量:1569.76
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]([H])(CSSC[C@H](NC(=O)CNC(=O)[C@@]([H])(NC1=O)[C@@H](C)O)C(O)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)NC(C(C)C)C(=O)N[C@@H](C)C(=O)N2
SMILES:[H][C@]12CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]([H])(CSSC[C@H](NC(=O)CNC(=O)[C@@]([H])(NC1=O)[C@@H](C)O)C(O)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)NC(C(C)C)C(=O)N[C@@H](C)C(=O)N2

Uroguanylin-15 (Rat) 是一种具备调节肾脏钠排泄功能的生物活性肽，尤其在摄入过量氯化钠时发挥作用。它与尿鸟苷蛋白及鸟苷蛋白相关，这两种肽能够激活肠道及肾脏中的鸟苷酸环化酶信号传导分子。尽管从尿液和十二指肠可分离出尿鸟苷素，大鼠结肠的提取物中却未观察到其存在。

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