Name: PROTAC Her3 Degrader-8
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT217584967
Cas No:2103331-95-7
常用名:PROTAC Her3 Degrader-8
IUPAC:(2R,4S)-1-[(2R)-2-[2-(4-{4-amino-3-[4-phenoxy-3-(prop-2-enamido)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}piperidin-1-yl)acetamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
IUPAC:(2R,4S)-1-[(2R)-2-[2-(4-{4-amino-3-[4-phenoxy-3-(prop-2-enamido)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}piperidin-1-yl)acetamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
InChI key:OVCGHYOSRVGRMJ-RQWACUIYSA-N

分子式:C49H55N11O6S
分子量:926.11
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ncsc1-c1ccc(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@H](NC(=O)CN2CCC(CC2)n2nc(-c3ccc(Oc4ccccc4)c(NC(=O)C=C)c3)c3c(N)ncnc23)C(C)(C)C)cc1
SMILES:Cc1ncsc1-c1ccc(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@H](NC(=O)CN2CCC(CC2)n2nc(-c3ccc(Oc4ccccc4)c(NC(=O)C=C)c3)c3c(N)ncnc23)C(C)(C)C)cc1

PROTACHer3 Degrader-8（Compound PP2）是一类PROTAC，能在体外及细胞实验中降解Her3蛋白，适用于HER家族蛋白调控的疾病研究。

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