Name: FMF-06-098-1
Rating: 5 (10 reviews)

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HIT ID:HIT217584989
Cas No:2769753-07-1
常用名:FMF-06-098-1
IUPAC:(2S,4R)-1-[(2S)-2-(3-{2-[2-(4-{4-[(5-chloro-4-{[2-(propane-2-sulfonyl)phenyl]amino}pyrimidin-2-yl)amino]phenyl}piperazin-1-yl)ethoxy]ethoxy}propanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
IUPAC:(2S,4R)-1-[(2S)-2-(3-{2-[2-(4-{4-[(5-chloro-4-{[2-(propane-2-sulfonyl)phenyl]amino}pyrimidin-2-yl)amino]phenyl}piperazin-1-yl)ethoxy]ethoxy}propanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
InChI key:KRCGDZOGRHISNJ-NQGAHEFWSA-N

分子式:C53H69ClN10O8S2
分子量:1073.77
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N2CCN(CCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)c3ccc(cc3)-c3scnc3C)C(C)(C)C)CC2)ncc1Cl
SMILES:CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N2CCN(CCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)c3ccc(cc3)-c3scnc3C)C(C)(C)C)CC2)ncc1Cl

FMF-06-098-1是一种多靶点蛋白降解剂。通过专一性降解作用，FMF-06-098-1针对多种激酶，能够有效降解AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1及WEE1等关键蛋白。

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