Name: RMC-6291
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT217586144
Cas No:2641998-63-0
常用名:RMC-6291
别名:RMC6291, RMC 6291, 2775304-30-6
IUPAC:2-(1-{1-[4-(dimethylamino)-4-methylpent-2-ynoyl]-4-fluoropiperidin-4-yl}-N-methylformamido)-N-{22-ethyl-21-[2-(1-methoxyethyl)pyridin-3-yl]-18,18-dimethyl-9,15-dioxo-5,16-dioxa-2,10,22,28-tetraazapentacyclo[18.5.2.1^{2,6}.1^{10,14}.0^{23,27}]nonacosa-1(25),20,23,26-tetraen-8-yl}-3-methylbutanamide
IUPAC:2-(1-{1-[4-(dimethylamino)-4-methylpent-2-ynoyl]-4-fluoropiperidin-4-yl}-N-methylformamido)-N-{22-ethyl-21-[2-(1-methoxyethyl)pyridin-3-yl]-18,18-dimethyl-9,15-dioxo-5,16-dioxa-2,10,22,28-tetraazapentacyclo[18.5.2.1^{2,6}.1^{10,14}.0^{23,27}]nonacosa-1(25),20,23,26-tetraen-8-yl}-3-methylbutanamide
InChI key:HJNFYLSFWYRSHS-UHFFFAOYSA-N

分子式:C55H78FN9O8
分子量:1012.282
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCn1c(c2CC(C)(C)COC(=O)C3CCCN(N3)C(=O)C(CC3CN(CCO3)c3ccc1c2c3)NC(=O)C(C(C)C)N(C)C(=O)C1(F)CCN(CC1)C(=O)C#CC(C)(C)N(C)C)-c1cccnc1C(C)OC
SMILES:CCn1c(c2CC(C)(C)COC(=O)C3CCCN(N3)C(=O)C(CC3CN(CCO3)c3ccc1c2c3)NC(=O)C(C(C)C)N(C)C(=O)C1(F)CCN(CC1)C(=O)C#CC(C)(C)N(C)C)-c1cccnc1C(C)OC

RMC-6291 是一种可口服且具有高效性的 KRASG12C(ON) 抑制剂，具有抗癌抗肿瘤活性，通过空间阻断 RAS 效应子结合来发挥作用。RMC-6291 阻断 ERK 信号传导，促使 KRASG12C 突变 H358 细胞凋亡。

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