Name: (R)-HH2853
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT217587186
Cas No:2202678-06-4
常用名:(R)-HH2853
IUPAC:N-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-6-methyl-1-(6-methylpyridazin-3-yl)-5-[(1R)-1-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]ethyl]indolizine-7-carboxamide
IUPAC:N-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-6-methyl-1-(6-methylpyridazin-3-yl)-5-[(1R)-1-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]ethyl]indolizine-7-carboxamide
InChI key:BIABSPVTTUDBEO-OAQYLSRUSA-N

分子式:C31H36F3N7O3
分子量:611.67
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c([C@@H](C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(C)nn1
SMILES:COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c([C@@H](C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccc(C)nn1

(R)-HH2853 是一种高效性 EZH2 抑制剂，对 EZH2-Y641F 的 IC50 <100 nM。(R)-HH2853 具有抗癌抗肿瘤活性，可用于自身免疫性疾病。

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