Name: Oxaliplatin-d10
Rating: 5 (10 reviews)

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分子式:C8H10N2O4Pt
分子量:403.323
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[2H]C1([2H])C([2H])([2H])C([2H])([2H])[C@@]2([2H])[N][Pt++]3([N][C@]2([2H])C1([2H])[2H])[O-]C(=O)C(=O)[O-]3
SMILES:[2H]C1([2H])C([2H])([2H])C([2H])([2H])[C@@]2([2H])[N][Pt++]3([N][C@]2([2H])C1([2H])[2H])[O-]C(=O)C(=O)[O-]3

Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 µM, respectively). It reduces tumor growth in an HCCLM3 mouse xenograft model when administered at doses of 5 or 10 mg/kg once per week. Formulations containing oxaliplatin have been used in the treatment of advanced colorectal cancer and as adjuvants in stage III colon cancer.

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