Name: Tebuconazole-d9
Rating: 5 (10 reviews)

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HIT ID:HIT217588437
Cas No:1246818-83-6
常用名:Tebuconazole-d9
IUPAC:1-(4-chlorophenyl)-4,4-di(2H3)methyl-3-[(1H-1,2,4-triazol-1-yl)methyl](5,5,5-2H3)pentan-3-ol
IUPAC:1-(4-chlorophenyl)-4,4-di(2H3)methyl-3-[(1H-1,2,4-triazol-1-yl)methyl](5,5,5-2H3)pentan-3-ol
InChI key:PXMNMQRDXWABCY-GQALSZNTSA-N

分子式:C16H22ClN3O
分子量:316.88
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[2H]C([2H])([2H])C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O)(CCc1ccc(Cl)cc1)Cn1cncn1
SMILES:[2H]C([2H])([2H])C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O)(CCc1ccc(Cl)cc1)Cn1cncn1

Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per day) administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses. It has a feminizing effect on male pups and a virializing effect on female pups. When administered to rats gestationally through postnatal day 42, tebuconazole (20 and 60 mg/kg per day) leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning......

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