Name: Ro 04-5595 free base
Rating: 5 (10 reviews)

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HIT ID:HIT217589468
Cas No:194089-07-1
常用名:Ro 04-5595 free base
IUPAC:1-[2-(4-chlorophenyl)ethyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
IUPAC:1-[2-(4-chlorophenyl)ethyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
InChI key:DSTWURHEHMZWEI-UHFFFAOYSA-N

分子式:C19H22ClNO2
分子量:331.84
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc2CCN(C)C(CCc3ccc(Cl)cc3)c2cc1O
SMILES:COc1cc2CCN(C)C(CCc3ccc(Cl)cc3)c2cc1O

Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific binding, defined with a new NR2B-specific antagonist Ro 04-5595 at 10 microM was fully inhibited by several compounds with the following rank order of affinities--Ro 25-6981 > CP-101,606 > Ro 04-5595 = ifenprodil >> eliprodil > haloperidol > spermine > spermidine > MgCl2 > CaCl2--and partially inhibited by competitive glutamate recognition site antagonists. Complementary high-resolution autoradiographic images using [3H]Ro04-5595 demonstrated strong binding in NR2B receptor-rich regions and low binding in cerebellum where NR2B concentration is low.

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