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  3. HIT217589596
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HIT217589596
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HIT217589596
  • HIT ID:HIT217589596
  • Cas No:2131223-85-1
  • 常用名:YW2065
  • IUPAC:1-(2-bromophenyl)-5-methyl-N-(quinolin-2-yl)-1H-pyrazole-4-carboxamide
    IUPAC:1-(2-bromophenyl)-5-methyl-N-(quinolin-2-yl)-1H-pyrazole-4-carboxamide
  • InChI key:ATYUYECWVYSPBS-UHFFFAOYSA-N
  • 分子式:C20H15BrN4O
  • 分子量:407.271
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cc1c(cnn1-c1ccccc1Br)C(=O)Nc1ccc2ccccc2n1
    SMILES:Cc1c(cnn1-c1ccccc1Br)C(=O)Nc1ccc2ccccc2n1
  • YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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