Name: YM-202074
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT217589957
Cas No:299900-83-7
常用名:YM-202074
IUPAC:N-cyclohexyl-11-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methyl-5-thia-2,7-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),3,6,8,10-pentaene-4-carboxamide
IUPAC:N-cyclohexyl-11-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methyl-5-thia-2,7-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),3,6,8,10-pentaene-4-carboxamide
InChI key:AQINBUDFKZIGCN-UHFFFAOYSA-N

分子式:C22H30N4O2S
分子量:414.57
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COCCN(C)Cc1ccc2nc3sc(cn3c2c1)C(=O)N(C)C1CCCCC1
SMILES:COCCN(C)Cc1ccc2nc3sc(cn3c2c1)C(=O)N(C)C1CCCCC1

YM-202074 is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM-202074 binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. It inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells).

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