Name: Lobeglitazone
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT217590352
Cas No:607723-33-1
常用名:Lobeglitazone
IUPAC:5-{[4-(2-{[6-(4-methoxyphenoxy)pyrimidin-4-yl](methyl)amino}ethoxy)phenyl]methyl}-1,3-thiazolidine-2,4-dione
IUPAC:5-{[4-(2-{[6-(4-methoxyphenoxy)pyrimidin-4-yl](methyl)amino}ethoxy)phenyl]methyl}-1,3-thiazolidine-2,4-dione
InChI key:CHHXEZSCHQVSRE-UHFFFAOYSA-N

分子式:C24H24N4O5S
分子量:480.54
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc(Oc2cc(ncn2)N(C)CCOc2ccc(CC3SC(=O)NC3=O)cc2)cc1
SMILES:COc1ccc(Oc2cc(ncn2)N(C)CCOc2ccc(CC3SC(=O)NC3=O)cc2)cc1

Lobeglitazone, also known as CKD-501, is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.

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