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  3. HIT217612792
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HIT217612792
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HIT217612792
  • HIT ID:HIT217612792
  • Cas No:
  • 常用名:CAY10508
  • IUPAC:1,3-bis(4-bromophenyl)-5-phenylimidazolidine-2,4-dione
    IUPAC:1,3-bis(4-bromophenyl)-5-phenylimidazolidine-2,4-dione
  • InChI key:ROASQEPZAKGACK-UHFFFAOYSA-N
  • 分子式:C21H14Br2N2O2
  • 分子量:486.163
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Brc1ccc(cc1)N1C(C(=O)N(C1=O)c1ccc(Br)cc1)c1ccccc1
    SMILES:Brc1ccc(cc1)N1C(C(=O)N(C1=O)c1ccc(Br)cc1)c1ccccc1
  • CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 µM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 465.00
    1

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