Name: ZIP
Rating: 5 (10 reviews)

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HIT ID:HIT217629962
Cas No:863987-12-6
常用名:ZIP
IUPAC:(2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-5-carbamimidamido-2-[(2S)-2-{2-[(2S)-5-carbamimidamido-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S,3S)-2-[(2S)-3-hydroxy-2-tetradecanamidopropanamido]-3-methylpentanamido]-3-(4-hydroxyphenyl)propanamido]pentanamido]pentanamido]acetamido}propanamido]pentanamido]pentanamido]-3-(1H-indol-3-yl)propanamido]pentanamido]hexanamido]-4-methylpentanoic acid
IUPAC:(2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-5-carbamimidamido-2-[(2S)-2-{2-[(2S)-5-carbamimidamido-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S,3S)-2-[(2S)-3-hydroxy-2-tetradecanamidopropanamido]-3-methylpentanamido]-3-(4-hydroxyphenyl)propanamido]pentanamido]pentanamido]acetamido}propanamido]pentanamido]pentanamido]-3-(1H-indol-3-yl)propanamido]pentanamido]hexanamido]-4-methylpentanoic acid
InChI key:CRKARHQCXWSUMV-HOHDCHNJSA-N

分子式:C90H154N30O17
分子量:1928.415
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O
SMILES:CCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O

Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

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