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  3. HIT217633232
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HIT217633232
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HIT217633232
  • HIT ID:HIT217633232
  • Cas No:
  • 常用名:CAY10649
  • IUPAC:(5Z)-2-(4-chlorophenyl)-5-[(4-methoxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one
    IUPAC:(5Z)-2-(4-chlorophenyl)-5-[(4-methoxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one
  • InChI key:BYPSEBXZQCBFIP-GDNBJRDFSA-N
  • 分子式:C17H12ClNO2S
  • 分子量:329.8
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1ccc(\C=C2/SC(=NC2=O)c2ccc(Cl)cc2)cc1
    SMILES:COc1ccc(\C=C2/SC(=NC2=O)c2ccc(Cl)cc2)cc1
  • 1CAY10649, a thiazolinone compound, directly inhibits 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with an IC50 value of 0.28 μM and in a soluble fraction of an S100 PMNL cell lysate with an IC50 value of 0.09 μM, following stimulation by calcium and arachidonic acid. This activity highlights its potential in mitigating inflammatory responses by targeting the biosynthesis of leukotrienes, substances implicated in various inflammatory processes such as neutrophil chemotaxis, increased vascular permeability, and smooth muscle contraction.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 780.00
    1

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