Rp-8-CPT-cAMPS sodium | AnyMole

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HIT217655215

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HIT217655215

HIT ID:HIT217655215
Cas No:
常用名:Rp-8-CPT-cAMPS sodium
IUPAC:sodium [(2R,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-hydroxy-2-oxo-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl]sulfanide
IUPAC:sodium [(2R,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-hydroxy-2-oxo-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl]sulfanide
InChI key:AWXMSJRRXLCVMW-ALHPSJIMSA-M

分子式:C16H14ClN5NaO5PS2
分子量:509.85
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4CO[P@]([S-])(=O)O[C@H]4[C@H]3O)c(Sc3ccc(Cl)cc3)nc12
SMILES:[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4CO[P@]([S-])(=O)O[C@H]4[C@H]3O)c(Sc3ccc(Cl)cc3)nc12

Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS .[1] It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II.2 By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.[2],[3]

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TargetMolSC
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货期
35日内发货
纯度
-
¥ 5,910.00
1

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