Name: ONO-AE3-208 sodium
Rating: 5 (10 reviews)

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HIT ID:HIT217656391
Cas No:
常用名:ONO-AE3-208 sodium
IUPAC:sodium 4-{4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanamido]phenyl}butanoate
IUPAC:sodium 4-{4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanamido]phenyl}butanoate
InChI key:FTOXXPATZUZQCF-UHFFFAOYSA-M

分子式:C24H20FN2NaO3
分子量:426.423
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na+].CC(C(=O)Nc1cc(ccc1CCCC([O-])=O)C#N)c1ccc(F)c2ccccc12
SMILES:[Na+].CC(C(=O)Nc1cc(ccc1CCCC([O-])=O)C#N)c1ccc(F)c2ccccc12

ONO-AE3-208 is an EP4 receptor antagonist with a Ki of 1.3 nM, exhibiting less potent activity against EP3, FP, and TP receptors (Ki values of 30, 790, and 2,400 nM, respectively), while showing no effect on other prostanoid receptors. In wild type mice, treatment with ONO-AE3-208, in conjunction with 3% dextran sodium sulfate, results in severe colitis characterized by epithelial loss, crypt damage, and inflammation, thereby mimicking the effects of EP4 deletion. Further, this compound has been utilized to investigate the role of EP4 signaling in various biological contexts, including immune and autoimmune responses, inflammation, and cancer.

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