Name: MMP-3 Inhibitor VIII
Rating: 5 (10 reviews)

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HIT ID:HIT217656405
Cas No:
常用名:MMP-3 Inhibitor VIII
别名:Stromelysin-1 Inhibitor VIII, Matrix Metalloproteinase-3 Inhibitor VIII
别名:Stromelysin-1 Inhibitor VIII, Matrix Metalloproteinase-3 Inhibitor VIII
IUPAC:2-(N-benzyl4-methoxybenzenesulfonamido)-N-hydroxy-4-methylpentanamide
IUPAC:2-(N-benzyl4-methoxybenzenesulfonamido)-N-hydroxy-4-methylpentanamide
InChI key:VKUYLANQOAKALN-UHFFFAOYSA-N

分子式:C20H26N2O5S
分子量:406.5
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(CC(C)C)C(=O)NO
SMILES:COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(CC(C)C)C(=O)NO

Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a critical enzyme involved in tissue remodeling and repair through its role in degrading extracellular matrix proteins, facilitating cell migration. This enzyme has been implicated in various physiological processes including vascular remodeling associated with aneurysm formation, wound healing, the progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII, a cell-permeable sulfonamide-based hydroxamic acid, effectively inhibits MMP-3 by binding to its active site (Ki = 23 nM), thus blocking its enzymatic activity. Additionally, this inhibitor has been demonstrated to suppress the activity of mouse macrophage metalloelastase MME/MMP-12, with an IC50 value of 13 nM, highlighting its potential utility in research on tissue remodeling and disease processes involving MMPs.

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