Name: PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
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HIT ID:HIT217656478
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常用名:PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
常用名:PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
别名:PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
别名:PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
IUPAC:tetrasodium (1S,2S,3S,4S,5R,6S)-3-({[(2R)-2,3-bis(hexadecanoyloxy)propoxy](oxido)phosphoryl}oxy)-5,6-bis(hydrogen phosphonatooxy)-2,4-dihydroxycyclohexyl hydrogen phosphate
IUPAC:tetrasodium (1S,2S,3S,4S,5R,6S)-3-({[(2R)-2,3-bis(hexadecanoyloxy)propoxy](oxido)phosphoryl}oxy)-5,6-bis(hydrogen phosphonatooxy)-2,4-dihydroxycyclohexyl hydrogen phosphate
InChI key:OKHWJEMVEFYEGE-RCBYKTLGSA-J

分子式:C41H78Na4O22P4
分子量:1138.907
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na+].[Na+].[Na+].[Na+].CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)O[C@@H]1[C@H](O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H](OP(O)([O-])=O)[C@H]1O)OC(=O)CCCCCCCCCCCCCCC
SMILES:[Na+].[Na+].[Na+].[Na+].CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)O[C@@H]1[C@H](O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H](OP(O)([O-])=O)[C@H]1O)OC(=O)CCCCCCCCCCCCCCC

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates.

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