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- HIT ID:HIT217656544
- Cas No:
- 常用名:ML-252 hydrochloride
- InChI key:XBYCQOZNTLUEDX-LMOVPXPDSA-N
- 分子式:C20H25ClN2O
- 分子量:344.88
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- ML-252 is a potent, selective inhibitor of the Kv7.2 voltage-gated potassium channel, demonstrating an IC50 value of 69 nM in patch clamp assays. It exists as the (S)-enantiomer, which is significantly more effective than both its (R)-enantiomer counterpart and the racemic mixture, with respective IC50 values of 944 nM and 160 nM. ML-252 exhibits high selectivity for Kv7.2 over other potassium channel subtypes and shows minimal activity against more than 68 G protein-coupled receptors, various transporters, L- and N-type calcium channels, K_ATP, and hERG potassium channels. However, it does inhibit the melatonin MT1 receptor by 61% at a 10 µM concentration.
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