Name: T2AA hydrochloride
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT217657106
Cas No:
常用名:T2AA hydrochloride
别名:T2-amino Alcohol
IUPAC:4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol hydrochloride
IUPAC:4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol hydrochloride
InChI key:ILDRWUYIAXQKLH-PPHPATTJSA-N

分子式:C15H16ClI2NO3
分子量:547.56
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.N[C@H](CO)Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1
SMILES:Cl.N[C@H](CO)Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1

T2AA, a proliferating cell nuclear antigen (PCNA) inhibitor, disrupts protein-protein interactions between PCNA and both a PIP-box-containing peptide (IC50= 1 μM) and full-length p21, reducing cellular colocalization of PCNA with DNA polymerase δ. This compound effectively inhibits DNA replication and cell proliferation in U2OS and HeLa cells in a concentration-dependent manner, additionally inducing S phase cell cycle arrest at a 20 μM concentration. Furthermore, T2AA enhances DNA double strand break formation alongside cisplatin in a neutral comet assay and augments cisplatin-induced reductions in clonogenic survival in HeLa and U2OS cells.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~