Name: Monohydroxy Melphalan hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT217664373
Cas No:
常用名:Monohydroxy Melphalan hydrochloride
常用名:Monohydroxy Melphalan hydrochloride
别名:Hydroxymelphalan
IUPAC:(2S)-2-amino-3-{4-[(2-chloroethyl)(2-hydroxyethyl)amino]phenyl}propanoic acid dihydrochloride
IUPAC:(2S)-2-amino-3-{4-[(2-chloroethyl)(2-hydroxyethyl)amino]phenyl}propanoic acid dihydrochloride
InChI key:UYAOCCFUQBFMKY-LTCKWSDVSA-N

分子式:C13H21Cl3N2O3
分子量:359.67
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.N[C@@H](Cc1ccc(cc1)N(CCO)CCCl)C(O)=O
SMILES:Cl.Cl.N[C@@H](Cc1ccc(cc1)N(CCO)CCCl)C(O)=O

Monohydroxy melphalan, a degradation product and DNA alkylating agent derived from melphalan, results from melphalan hydrolysis in aqueous solutions such as cell culture medium and human plasma. It enhances DNA adducts in ML-1 myeloblastic leukemia cells based on concentration and induces cytotoxicity with an IC50 value of 28.1 μg/ml.

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