Name: N-CBZ-Phe-Arg-AMC
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT217665244
Cas No:65147-22-0
常用名:N-CBZ-Phe-Arg-AMC
别名:Z-Phe-Arg-Amc, Z-FR-AMC
IUPAC:benzyl N-[(1S)-1-{[(1S)-4-carbamimidamido-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]butyl]carbamoyl}-2-phenylethyl]carbamate
IUPAC:benzyl N-[(1S)-1-{[(1S)-4-carbamimidamido-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]butyl]carbamoyl}-2-phenylethyl]carbamate
InChI key:ZZGDDBWFXDMARY-SVBPBHIXSA-N

分子式:C33H36N6O6
分子量:612.687
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1cc(=O)oc2cc(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc3ccccc3)NC(=O)OCc3ccccc3)ccc12
SMILES:Cc1cc(=O)oc2cc(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc3ccccc3)NC(=O)OCc3ccccc3)ccc12

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a substrate for serine proteases, including cathepsins, kallikrein, and plasmin. The substrate exhibits absorption/emission at 330/390 nm (weak fluorescence), while the end product (AMC) shows absorption/emission at 342/441 nm (strong fluorescence).

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