Name: 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
Rating: 5 (10 reviews)

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HIT ID:HIT217677227
Cas No:
常用名:9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
常用名:9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
IUPAC:sodium (9Z,11E)-octadeca-9,11-dienoate
IUPAC:sodium (9Z,11E)-octadeca-9,11-dienoate
InChI key:AHGUYUKYUXMSJU-QSZGMOAKSA-M

分子式:C18H31NaO2
分子量:302.434
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na+].CCCCCC\C=C\C=C/CCCCCCCC([O-])=O
SMILES:[Na+].CCCCCC\C=C\C=C/CCCCCCCC([O-])=O

9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-conjugated linoleic acid reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration inob/obmice. It also increases body weight gain and body fat in weanling mice.4

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