Name: MYF-03-176
Rating: 5 (10 reviews)

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HIT ID:HIT217705105
Cas No:2857937-59-6
常用名:MYF-03-176
别名:MYF03-176, MYF-03176, MYF03176
IUPAC:2-fluoro-1-[(3R,4R)-3-[(pyrimidin-2-yl)amino]-4-{[4-(trifluoromethyl)phenyl]methoxy}pyrrolidin-1-yl]prop-2-en-1-one
IUPAC:2-fluoro-1-[(3R,4R)-3-[(pyrimidin-2-yl)amino]-4-{[4-(trifluoromethyl)phenyl]methoxy}pyrrolidin-1-yl]prop-2-en-1-one
InChI key:KVAWNRUJSYWYJX-HZPDHXFCSA-N

分子式:C19H18F4N4O2
分子量:410.373
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:FC(=C)C(=O)N1C[C@@H](Nc2ncccn2)[C@@H](C1)OCc1ccc(cc1)C(F)(F)F
SMILES:FC(=C)C(=O)N1C[C@@H](Nc2ncccn2)[C@@H](C1)OCc1ccc(cc1)C(F)(F)F

MYF-03-176 is an orally active TEAD1/3/4 inhibitor with IC₅₀ values of 47/32/71 nM, respectively. It also inhibits TEAD transcriptional activity and cell growth in NCI-H226 cells, exhibiting antitumour activity in malignant pleural mesothelioma (MPM) cells with defective Hippo signalling and in mouse xenograft models.

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