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  3. HIT217705569
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HIT217705569
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HIT217705569
  • HIT ID:HIT217705569
  • Cas No:
  • 常用名:AF-353 hydrochloride
  • 别名:P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353
    别名:P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353
  • IUPAC:5-[5-iodo-4-methoxy-2-(propan-2-yl)phenoxy]pyrimidine-2,4-diamine hydrochloride
    IUPAC:5-[5-iodo-4-methoxy-2-(propan-2-yl)phenoxy]pyrimidine-2,4-diamine hydrochloride
  • InChI key:QRBBKDZPXABQPE-UHFFFAOYSA-N
  • 分子式:C14H18ClIN4O2
  • 分子量:436.68
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cl.COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I
    SMILES:Cl.COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I
  • This novel compound is an orally bioavailable antagonist of P2X3/P2X2/3 receptors, exhibiting potent activity with a pIC50 of 8 in both human and rat, and a pIC50 of 7.3 specifically for the human P2X2/3 receptor. It demonstrates high brain penetration, evidenced by a brain to plasma ratio of 6, and effectively blocks agonist-evoked intracellular Ca2+ flux and inward currents within the nanomolar range (10 nM to 1 µM) in cell lines that express human P2X3 and P2X2/3 receptors recombinantly. The compound also shows favorable pharmacokinetic properties, with a half-life (t1/2) of 1.63 hours and a time to reach maximum concentration (Tmax) of 30 minutes.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 615.00
    1

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