Name: Desethoxy Quetiapine hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT217705629
Cas No:
常用名:Desethoxy Quetiapine hydrochloride
常用名:Desethoxy Quetiapine hydrochloride
别名:O-Desalkylquetiapine
IUPAC:2-(4-{2-thia-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,9,11,13-heptaen-10-yl}piperazin-1-yl)ethan-1-ol dihydrochloride
IUPAC:2-(4-{2-thia-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,9,11,13-heptaen-10-yl}piperazin-1-yl)ethan-1-ol dihydrochloride
InChI key:OXKMTOMGUPCOBA-UHFFFAOYSA-N

分子式:C19H23Cl2N3OS
分子量:412.37
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.OCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
SMILES:Cl.Cl.OCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12

Desethoxy quetiapine, an active metabolite of the atypical antipsychotic quetiapine, primarily forms through the action of the cytochrome P450 (CYP) isoform CYP3A5. This compound binds to dopamine D2 receptors with an IC50 value of 1,330 nM. In vivo, desethoxy quetiapine at dosages of 20 and 40 mg/kg mitigates dopamine receptor agonist apomorphine-induced climbing behavior and ameliorates swimming deficits in mice, showcasing its potential modulatory effects on dopamine-mediated behaviors.

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