Name: ζ-Stat trisodium
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT217727797
Cas No:
常用名:ζ-Stat trisodium
别名:ζ-Stat trisodium, NSC37044 trisodium
IUPAC:trisodium 8-hydroxynaphthalene-1,3,6-trisulfonate
IUPAC:trisodium 8-hydroxynaphthalene-1,3,6-trisulfonate
InChI key:VQXXRDCDIFAODW-UHFFFAOYSA-K

分子式:C10H5Na3O10S3
分子量:450.29
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na+].[Na+].[Na+].Oc1cc(cc2cc(cc(c12)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O
SMILES:[Na+].[Na+].[Na+].Oc1cc(cc2cc(cc(c12)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O

ζ-Stat trisodium (NSC37044 trisodium) is a potent and selective inhibitor of protein kinase C-ζ (PKC-ζ), exhibiting an IC50 of 5 μM. It effectively suppresses the proliferation of melanoma cell lines and promotes apoptosis. Moreover, ζ-Stat trisodium demonstrates notable antitumor activity in vitro.

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