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  3. HIT218452769
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HIT218452769
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HIT218452769
  • HIT ID:HIT218452769
  • Cas No:
  • 常用名:UNC2170 maleate
  • IUPAC:3-bromo-N-[3-(tert-butylamino)propyl]benzamide; but-2-enedioic acid
    IUPAC:3-bromo-N-[3-(tert-butylamino)propyl]benzamide; but-2-enedioic acid
  • InChI key:WCAATDGMINWXPJ-UHFFFAOYSA-N
  • 分子式:C18H25BrN2O5
  • 分子量:429.311
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:OC(=O)C=CC(O)=O.CC(C)(C)NCCCNC(=O)c1cccc(Br)c1
    SMILES:OC(=O)C=CC(O)=O.CC(C)(C)NCCCNC(=O)c1cccc(Br)c1
  • 53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
    纯度
    -
    ¥ 795.00
    1

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