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  3. HIT218543124
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HIT218543124
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HIT218543124
  • HIT ID:HIT218543124
  • Cas No:
  • 常用名:1-Arachidonoyl Glycerol
  • 别名:1-AG
  • IUPAC:2,3-dihydroxypropyl icosa-5,8,11,14-tetraenoate
    IUPAC:2,3-dihydroxypropyl icosa-5,8,11,14-tetraenoate
  • InChI key:DCPCOKIYJYGMDN-UHFFFAOYSA-N
  • 分子式:C23H38O4
  • 分子量:378.553
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCCCCC=CCC=CCC=CCC=CCCCC(=O)OCC(O)CO
    SMILES:CCCCCC=CCC=CCC=CCC=CCCCC(=O)OCC(O)CO
  • 2-Arachidonoylglycerol (2-AG) is identified as a more potent endogenous cannabinoid ligand compared to its analogue, 1-Arachidonoylglycerol (1-AG), exhibiting 10 to 100 times the ligand binding affinity and agonist activity at the CB1 receptor, thus making it a natural ligand. However, 2-AG's chemical instability leads to rapid isomerization to 1-AG (also referred to as 1(3)-AG) both in vitro and in vivo. This isomerization process, where 1-AG becomes a frequent contaminant in synthetic 1-AG preparations, significantly decreases their cannabinergic potency. Furthermore, 1-AG is characterized as a weak CB1 receptor agonist with potential for other pharmacological effects.
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 420.00
    1
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,080.00
    1

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