Name: D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
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HIT ID:HIT218589663
Cas No:
常用名:D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
常用名:D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
别名:Ins(1,4,5,6)-P4, D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
别名:Ins(1,4,5,6)-P4, D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
IUPAC:tetrasodium (1S,2S,3R,4R,5S,6R)-2,3,6-tris(hydrogen phosphonatooxy)-4,5-dihydroxycyclohexyl hydrogen phosphate
IUPAC:tetrasodium (1S,2S,3R,4R,5S,6R)-2,3,6-tris(hydrogen phosphonatooxy)-4,5-dihydroxycyclohexyl hydrogen phosphate
InChI key:DZJJWPAQUIBBLR-YJFYTHTCSA-J

分子式:C6H12Na4O18P4
分子量:587.998
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@@H]1OP(O)([O-])=O
SMILES:[Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@@H]1OP(O)([O-])=O

D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.[1] D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella. Ins(1,4,5,6)-P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins(1,4,5,6)-P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.[2]

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