Name: ANO1-IN-4
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HIT ID:HIT218637839
Cas No:2098490-06-1
Common Name:ANO1-IN-4
IUPAC:2-(2-bromo-2,2-difluoroacetamido)-N-(2-methylphenyl)-4H,5H,6H,7H,8H-cyclohepta[b]thiophene-3-carboxamide
IUPAC:2-(2-bromo-2,2-difluoroacetamido)-N-(2-methylphenyl)-4H,5H,6H,7H,8H-cyclohepta[b]thiophene-3-carboxamide
InChIKey:VLFFBQAZZDJCHK-UHFFFAOYSA-N

Molecular Formula:C19H19BrF2N2O2S
Molecular Weight:457.33
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Br)sc2CCCCCc12
SMILES:Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Br)sc2CCCCCc12

ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC₅₀ of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.

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